Katerina Akassoglou, a leading neuroimmunologist at the Gladstone Institutes, dives into the intricate relationship between blood, brain health, and inflammation, particularly in the context of COVID-19. She discusses groundbreaking research linking the SARS-CoV-2 spike protein to fibrin and its inflammatory impact on the brain. The conversation highlights the nuances of neuroinflammation in long COVID and explores potential therapeutic strategies. Akassoglou also emphasizes the importance of collaboration in tackling these complex health issues and the role of foundational research in vaccine development.