In this engaging discussion, Kate Olmstead, a woman with Down syndrome, shares her firsthand experience with the emotional complexities of living with Alzheimer's disease. Joining her is John Hardy, a renowned neuroscientist who sheds light on the amyloid hypothesis and its connection to chromosome 21. They tackle the urgent need for inclusive clinical trials and improved treatment access for individuals with Down syndrome. The conversation explores the intertwined futures of these two conditions and highlights the potential for scientific breakthroughs through better representation in research.