Julia M. Shifman

Researcher at The Hebrew University of Jerusalem focusing on targeting Ras proteins with protein engineering

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Jul 14, 2023 • 9min

Targeting Ras in Cancer Therapies: Advances in Protein Engineering

The podcast explores the crucial role of Ras in cancer development, focusing on how inhibitors can target Ras mutations in pancreatic, colorectal, and lung cancers. Advances in engineering Ras binders using protein scaffolds, experimental evolution, and computational techniques are highlighted for more effective treatment. Intracellular protein delivery techniques like fusion with CPPs and nanoparticle coupling offer innovative strategies for precise Ras inhibitor delivery in cells, enhancing targeted cancer treatments.