Joyce O’Shaughnessy

Medical oncologist and clinical investigator affiliated with Sarah Cannon Research Institute and Baylor University Medical Center, known for expertise in breast cancer clinical trials and practical treatment strategies in community oncology.

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Nov 29, 2025 • 59min

Metastatic Breast Cancer — Optimizing the Use of Oral Selective Estrogen Receptor Degraders: Part 2

Dr. Rinath M Jeselsohn, a specialist in endocrine therapy resistance at Dana-Farber, and Dr. Joyce O’Shaughnessy, known for her expertise in breast cancer trials, dive into the latest in metastatic breast cancer treatments. They discuss the efficacy of oral selective estrogen receptor degraders, the importance of ctDNA testing for ESR1 mutations, and choices for therapy post-CDK4/6 progression. Insights into combination therapies and recent trial results illuminate the complexities of treatment strategies, providing a comprehensive overview for clinicians.

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