Jorrit de Jong and Amy Edmondson discuss the challenges of collaborative governing to solve intractable problems. They highlight the importance of building trust, creating a culture of safety, and being empowered to try, fail, and learn from mistakes. Finding an entry point is key, as shown by a group in Manchester that tackled homelessness and opioid abuse. They explore the applicability of cross-boundary collaborations in different contexts and provide recommendations for encouraging such collaborations.