Jonathan Lambert, a science journalist specializing in psychedelics and mental health, dives into the promising potential of substances like ecstasy and mushrooms in treating conditions such as PTSD and depression. He discusses the complexities of conducting unbiased clinical trials and the influence of participants’ knowledge on research outcomes. The conversation also emphasizes the vital role of therapeutic context, innovative study designs, and the need for a reevaluation of current research models to better understand the healing power of psychedelics.