In this engaging conversation, Prof. Jonathan Hourihane, a leading authority on pediatric peanut allergy and immunotherapy, dives into the complexities of Type 1 hypersensitivity reactions. He discusses groundbreaking strategies for managing peanut allergies, including the impact of early allergen exposure. The dialogue highlights oral and epicutaneous immunotherapy, revealing pivotal clinical trials like the Artemis trial. Prof. Hourihane also shares insights on future innovations and the need for proactive public health guidelines to enhance treatment outcomes for children.