John Semple

Researcher at Lund University focused on transfusion-related acute lung injury (TRALI); presented findings on mitochondrial DNA acting via recipient TLR9 as a first hit in murine TRALI.

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Nov 13, 2025 • 19min

New Research: Mitochondrial DNA in TRALI and Venetoclax-Obinituzumab in CLL Trials

Join Dr. John Semple, a researcher at Lund University specializing in transfusion-related lung injuries, as he discusses how mitochondrial DNA acts as a critical trigger for TRALI via TLR9 signaling. Dr. Othman Al-Sawaf studies chronic lymphocytic leukemia and reveals surprising insights about patient fitness, highlighting that both fit and unfit patients respond similarly to treatment with venetoclax and obinutuzumab. Their research challenges existing views and suggests new pathways for understanding and treating these conditions.

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