In this discussion, John Phay, a clinical professor and co-discoverer of parathyroid near-infrared autofluorescence, dives into its origins and clinical impact. Priya Dedhia, an assistant professor specializing in endocrine surgery, shares insights on comparing autofluorescence with indocyanine green (ICG) for identifying parathyroids. Samantha Ruff, a surgical oncology fellow, reviews studies highlighting how autofluorescence reduces early hypocalcemia, making a case for its use in complex surgeries. Together, they explore the future of surgical adjuncts in endocrine procedures.