Dr. Sahil Parikh, an interventional cardiologist from NYC, and Dr. John Park, a vascular surgeon in Omaha, discuss the evolving landscape of drug-coated balloons (DCBs) for peripheral artery disease. They unpack the historical controversies around Paclitaxel-coated devices and the recent FDA guidance that has renewed interest in their use. The doctors share insights on patient selection, treatment algorithms, and the impact of DCBs on claudication symptoms. They emphasize the balance between effective patient care and healthcare costs, advocating for confidence in DCB implementation.