John Moore, a microbiology professor at Weill Cornell Medicine, and Alina Chan, a scientific advisor at the Broad Institute, dive deep into the controversial lab leak theory of COVID-19's origins. They dissect the ongoing debate between natural zoonotic transmission and the lab leak hypothesis, highlighting key evidence and historical contexts. The conversation touches on the intricate practices of coronavirus research and raises critical questions about biosafety. Additionally, they reflect on the complexities faced by scientists amid misinformation and polarization in public discourse.