John Lepore
Physician-scientist and biotech executive serving as CEO & President of ProFound Therapeutics and CEO-Partner at Flagship Pioneering, with a long tenure at GSK leading research and drug-discovery efforts.
Best podcasts with John Lepore
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Dec 3, 2025 • 35min
John Lepore, CEO & President - ProFound Therapeutics, on Proteome, AI, & Bold First-in-Class Drugs
In this engaging discussion, John Lepore, a physician-scientist and CEO of ProFound Therapeutics, shares insights from his remarkable career in biotech. He reveals how he transitioned from academia to leading drug discovery at GSK and discusses the challenges of creating first-in-class medicines. John emphasizes the significance of uncovering thousands of previously unrecognized human proteins and how AI can accelerate drug discovery. He also offers valuable advice on biotech leadership, hiring, and the importance of building solid pharma partnerships to pursue groundbreaking therapies.
Mar 13, 2025 • 40min
EP 178: Expanding the human proteome to facilitate drug discovery with John Lepore of ProFound Therapeutics
John Lepore, physician-scientist and CEO of ProFound Therapeutics, shares insights on expanding the human proteome to discover novel drug targets. He discusses the creation of the ProFoundry atlas and its role in integrating genomic data. The conversation highlights innovative drug discovery methods, collaboration with Pfizer for obesity research, and strategies for biotech firms to engage with pharma partners. John’s background as a cardiologist informs his approach, emphasizing the connection between scientific research and patient care.
