John Lepore

Physician-scientist and CEO of ProFound Therapeutics. Leads a team focused on expanding the human proteome to identify novel drug targets and drug discovery.

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Mar 13, 2025 • 40min

EP 178: Expanding the human proteome to facilitate drug discovery with John Lepore of ProFound Therapeutics

John Lepore, physician-scientist and CEO of ProFound Therapeutics, shares insights on expanding the human proteome to discover novel drug targets. He discusses the creation of the ProFoundry atlas and its role in integrating genomic data. The conversation highlights innovative drug discovery methods, collaboration with Pfizer for obesity research, and strategies for biotech firms to engage with pharma partners. John’s background as a cardiologist informs his approach, emphasizing the connection between scientific research and patient care.