Stay up-to-date with advances in chronic kidney disease (CKD)! Join our esteemed Chief of Nephrology at Kashlak Memorial Hospital, Dr. Joel Topf, as he leads us through the latest on SGLT2 inhibitors, finerenone, potassium binders, and treatment of CKD-associated metabolic acidosis. Claim free CME for this episode at curbsiders.vcuhealth.org! Episodes | Subscribe | Spotify | YouTube | Mailing List | askcurbsiders@gmail.com | Swag! | Free CME! Show Segments Intro, disclaimer, guest bio Case from Kashlak SGLT2i: when to initiate SGLT2i: adverse effects Finerenone Potassium binders Treatment of CKD-associated metabolic acidosis  Outro Credits Writer, Producer, Show Notes, Infographics, and Cover Art: Malini Gandhi Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP    Reviewer: Leah Witt MD Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Technical Production: PodPaste Guest: Dr. Joel Topf MD Sponsor: Better Help Visit betterhelp.com/curb today to get 10% off your first month.  Sponsor: Birch Living Birch is giving 20% off all mattresses and 2 free eco-rest pillows at birchliving.com/curb.  Sponsor: PanaceaFinancial Visit panaceafinancial.com to open a free account.  Full transcript available HERE

Join Dr. Joel Topf, Chief of Nephrology, as he dives into the intricate world of acute kidney injury (AKI). With humor and expertise, he demystifies common myths around nephrotoxicity, including risks tied to vancomycin and NSAIDs. Learn about the critical factors in diagnosing and managing AKI, particularly in high-risk patients. From understanding urine output to navigating the challenges of acute interstitial nephritis, Dr. Topf shares valuable tips for both clinicians and curious minds alike.

Explore the exciting world of SGLT2 inhibitors with Dr. Harish Seethapathy, Dr. Matt Sparks, and Dr. Joel Topf. They discuss the mechanisms and benefits of these inhibitors for glucose control, cardiovascular health, and chronic kidney disease. The speakers delve into the hemodynamics and regulation of glomerular filtration and explore the various mechanisms of action of SGLT2 inhibitors, emphasizing their impact on inflammation, fibrosis, insulin sensitivity, and more. They also discuss the cancellation of Neffmatin and make predictions for the winners in the NephMadness 2020 SGLT2i region.

Join kidney specialist Dr. Joel Topf, known for his nephrology expertise, and heart specialist Dr. Sadiya Khan, who focuses on cardiovascular health, as they dive into the complexities of cardiorenal syndrome. They discuss managing the 'creatinine bump' during treatment, explore the use of SGLT-2 inhibitors, and tackle the challenges of diuretic resistance. Their insights on monitoring cardiac biomarkers in chronic kidney disease patients add depth, emphasizing the intertwined nature of heart and kidney health.

Dr. Joel Topf, a master nephrologist, discusses hyponatremia in critical illness, including diagnosis and management. They also dive into the complexities of osmotic demyelination syndrome and the importance of considering the interplay between potassium and sodium levels. The podcast emphasizes the need for a logical and systematic approach to managing critically ill patients with hyponatremia.

Kashlak’s esteemed Chief of Nephrology, Dr Joel Topf @kidney_boy walks us through the evaluation and differentiation of nephrotic syndrome and glomerulonephritis. Embrace the kidney again as we sort the different diagnostics, managements, and prognosis for these two pathologies. Episodes | Subscribe | Spotify | Swag! | Top Picks | Mailing List | thecurbsiders@gmail.com | Free CME! Credits Producer, writer, infographic, cover art: Elena Gibson MD Hosts: Elena Gibson MD, Stuart Brigham MD; Matthew Watto MD, FACP; Paul Williams MD, FACP Editor: Emi Okamoto MD (written); Clair Morgan of nodderly.com (audio) Guest: Joel Topf MD Time Stamps* *Note: Time Stamps refer to ad free version Intro, disclaimer, guest bio – 00:00 Picks of the Week – 3:10 Case from Kashlak – 6:30 Nephrotic syndrome definition- 12:30 Proteinuria evaluation – 15:04 Additional lab testing – 27:08; 40:09 Types of Nephrotic syndrome – 30:15 Mechanism of nephrotic syndrome edema – 33:08 Management of nephrotic syndrome – 44:07 Second Kashlak Case- Glomerulonephritis – 55:05 Treatment of glomerulonephritis – 65:05 Outro and post-credits scene – 73:20 Sponsor: The American College of Physicians Join us for ACP Internal Medicine Meeting 2021: Virtual Experience for 3 days of interactive, livestreaming education and events April 29 through May 1—plus on-demand post-meeting access to CME credit for up to 3 years. “Early Bird” members get an additional $80 registration discount on top of their member discount. Visit annualmeeting.acponline.org and use the code IM21CURB. Register now—Early Bird savings end January 31st! Sponsor: VCU Health CE The Curbsiders are partnering with VCU Health Continuing Education to offer FREE continuing education credits for physicians and other healthcare professionals. Visit curbsiders.vcuhealth.org and search for this episode to claim credit.

Dr. Ryann Sohaney, Dr. Deborah Clegg, and Dr. Joel Topf discuss hyperkalemia in CKD in this episode. They examine the use of potassium binders, challenge low-potassium diets, and explore the influence of exercise on serum potassium. They also introduce NephMadness 2020 and discuss managing hyperkalemia, dietary changes, salt substitutes, and the benefits of exercise for CKD patients.

Dr. Joel Topf discusses the significance of cystatin C in estimating GFR, especially in older individuals and those with varying muscle mass. He explores the challenges of predicting kidney disease outcomes in the elderly and the importance of accurate GFR calculation. The podcast delves into incorporating advanced testing methods like cystatin C and creatinine for predicting outcomes and enhancing eGFR estimation for personalized risk assessment.

Dr. Joel Topf, Kashlak's esteemed Chief of Nephrology, discusses the evaluation and differentiation of nephrotic syndrome and glomerulonephritis. Topics include proteinuria evaluation, management of nephrotic syndrome, and treatment of glomerulonephritis.

Three nephrology experts discuss inpatient hypertension, including how to respond to overnight nursing calls for elevated blood pressures and the role of treating hypertensive urgency in the hospital. They also explore the question of whether ACE-inhibitors are dangerous to give or hold during an operation. This episode provides insights into the role of anti-hypertensives in the inpatient setting.