Joan Mannick, M.D., co-founder of Restore Bio, and Nir Barzilai, M.D., director at the Institute for Aging Research, delve into the fascinating worlds of rapamycin and metformin. They discuss how these compounds may enhance longevity and boost immune responses, particularly in reducing COVID-19 mortality. Nir shares insights from his clinical trial testing metformin's pro-longevity effects, while Joan explains rapalogs' immune-enhancing capabilities. The potential roles of these drugs in combating neurodegenerative diseases also spark engaging discussions.