Jay L Koyner, a Professor of Medicine specializing in acute kidney injury (AKI) and dialysis, and Sarah Faubel, a Professor known for her contributions to medical education and renal health, join the discussion. They delve into the implications of the AKIKI-2 study on dialysis timing in AKI, emphasizing that late initiation may not worsen mortality outcomes. The conversation also touches on managing fluid volume in critically ill patients, innovative biomarkers for diagnosing AKI, and exciting developments in NAD therapy related to renal health.