David B. Yaden, a psychedelic researcher, and Jared T. Hinkle, a medical doctor specializing in psychedelic studies, dive into the intricate world of classic psychedelics. They discuss a recent systematic review highlighting adverse events linked to substances like psilocybin and LSD. The conversation emphasizes the need for balanced evaluations of risks and benefits, improving reporting standards, and the necessity for long-term monitoring in clinical studies. Tune in for insights on psychedelics' therapeutic potential and the ongoing challenges in their research!