Janine Austin Clayton, MD, is the Associate Director for Research on Women's Health at the NIH, dedicated to bridging knowledge gaps in women's health. She highlights the evolution of NIH policies since 1986, advocating for inclusive research that considers sex differences. Recent findings from studies like GTEC and MOTORPAC reveal crucial variations in health outcomes between genders. Clayton discusses new initiatives and funding opportunities aimed at fostering comprehensive women's health research, paving the way for personalized healthcare strategies.