Jan Felix Drexler, a virology expert from Berlin, and Fernando Bozza, a specialist in infectious diseases from Brazil, delve into the pressing issues surrounding the Oropouche virus. They discuss their recent laboratory-based study on the virus's ecology and its broader implications for arbovirus transmission in Latin America. Key topics include the challenges posed by urbanization, the impact of COVID-19 on mosquito control efforts, and the need for improved diagnostics and healthcare systems. Their insights highlight the urgency for collaborative public health strategies to combat emerging infections.