Dr. Jamie Almandoz, an expert in obesity and cardiovascular disease risk, joins the hosts to discuss the impact of obesity on cardiovascular health. They explore the question of whether it is possible to be healthy at any size and highlight the biomechanical and psychosocial challenges of obesity. They also delve into the effects of different types of adipose tissue on metabolic health and organ systems. The speakers analyze the results of a semaglutide trial for obesity and cardiovascular disease, discussing the significant risk reduction in major adverse cardiovascular events. Lastly, they discuss the percentage of body weight reduction needed for cardiovascular disease benefits.