In this engaging discussion, James Lederer, an associate professor specializing in neutrophil research, and Elizabeth Kovacs, an expert on aging and lung inflammation, delve into the intricate responses of the immune system to trauma. They explore fascinating topics such as the role of natural immune mice in research and how gut, lungs, and brain function together during injury. Additionally, they discuss the effects of alcohol on burn patients and the implications of aging on lung health, shedding light on the complexities of immunity.