Charlie Cheever and James Ide, co-founders of Expo, share their journey in building a framework that simplifies cross-platform mobile app development with React Native. They discuss how Expo's pre-built APIs expedite access to hardware features and enhance the user experience. The duo highlights challenges faced by developers in achieving a native app feel and explains the benefits of cloud services, like automatic app submission. Their insights emphasize a collaborative approach to empowering developers and fostering innovation within the mobile development community.