James D. Douketis, MD, a specialist in anticoagulant management from McMaster University, teams up with Kristin L. Walter, MD, MS, a JAMA Deputy Editor with a focus on clinical research. Together, they dive into the nuances of managing direct oral anticoagulants (DOACs) during surgical procedures. They explore bleeding risks, the pharmacokinetics of DOACs, and tailored strategies for individual patient safety. The duo also discusses the emerging role of Dolex in perioperative care and stresses the need for healthcare professionals to stay informed.