Stephan Achenbach, a leading cardiology expert, joins Carlos Aguiar, a top atrial fibrillation researcher, Jane Armitage, a clinician renowned for her work on clinical trials, and Isabel Deisenhofer, an authority on cardiovascular study evaluation. They dive into strategic decisions in managing atrial fibrillation, discussing new guidelines that emphasize rhythm control and catheter ablation. The group also explores the importance of designing reliable clinical trials and the need for patient involvement in advanced cardiac treatment decisions.