Fashion designer Isaac Mizrahi joins the show to discuss dinner parties with Nora Ephron, being a young gay designer during the AIDs crisis, and career risks. They also touch on sugar in food, Isaac's design career, balancing parenthood and social life, being a gay man in the fashion industry, ending a relationship with Chanel, collaborating with Target, and their love for research.

Isaac Mizrahi interviews journalist Soledad O'Brien. They discuss her defining moment as a journalist, her husband's support, CNN's Britney Spears story, and challenges faced by working mothers. They also talk about impartiality in journalism, navigating parenthood, supportive relationships, appearance restrictions, and promoting 'Matter of Fact' and 'Hello Isaac' podcast.