
Irene Ghobrial
Clinician at Dana-Farber Cancer Institute, Boston, MA
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Apr 19, 2023 • 11min
iwMyeloma Session II: the tumor microenvironment and mechanisms of resistance to targeted therapies
Irene Ghobrial and Paola Neri discuss the tumor microenvironment, immune microenvironment, and resistance mechanisms to targeted therapies in multiple myeloma. Topics include T cell fitness, checkpoint inhibitors, stromal cells, cytokines, chemokines, CAR T cells, IL-6, STAT-3 signaling pathways, therapy effects on immune system and tumor cells, post-therapy treatments, and understanding resistance mechanisms.