What if you could reverse the age of your heart...without leaving home?

In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer of Timeline, to reveal groundbreaking science that targets cardiovascular aging at the cellular level. You’ll discover how mitochondrial decline drives heart failure, why postmenopausal women face skyrocketing cardiac risks, and how one powerful molecule, Urolithin A, can rejuvenate your heart’s energy systems.

Dr. Singh shares clinical research showing how Urolithin A improves mitochondrial function, boosts endurance, and may even reverse biological aging markers in the heart. You’ll also learn how simple lifestyle biohacks, combined with cellular nutrition, can protect your cardiovascular health and extend your healthspan.

What You’ll Learn in This Episode:

• The link between mitochondrial decline and heart failure

• Why women’s cardiac risk skyrockets after menopause

• How Urolithin A stimulates mitophagy and energy renewal

• New human clinical data on reversing cardiac aging markers

• Biohacking strategies to fortify your cardiovascular health

• How to optimize endurance, recovery, and heart resilience

THANK YOU TO OUR SPONSORS!

-STEMREGEN | Head to https://www.stemregen.co/dave for 20% off your first order.

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Timeline Website – https://www.timeline.com/partners/dave-asprey

• Timeline Instagram - https://www.instagram.com/timeline_longevity/

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

Timestamps:

• 00:00 — Trailer

• 02:11 — Supplements that help

• 03:05 — Long-term benefits

• 04:38 — Stacking with lifestyle

• 22:19 — Heart health connection

• 29:39 — Mitochondria & brain function

• 33:04 — Glymphatic system & Alzheimer’s

• 33:53 — Bed height & brain health

• 34:18 — Why mitochondria matter

• 35:43 — Inflammation & dysfunction

• 38:12 — Transplants & consciousness

• 39:19 — Meditation’s effects

• 40:33 — The ultimate biohacking stack

• 43:06 — Creatine for sleep & focus

• 50:00 — Fertility insights

• 57:23 — Skin health

• 01:00:28 — Final thoughts

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Inge Klöpfer

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