This week, guests Hiranya Peiris, a Professor of Astrophysics, and Adam Riess, a Professor of Physics and Astronomy, dive into the puzzling discrepancies in measurements of the Hubble constant. They discuss the implications of these inconsistencies for our understanding of the cosmos and whether new physics might be necessary. The conversation also touches on a groundbreaking synthetic E. coli genome, showcasing how innovative genetic coding can reshape biology. The legacy of explorer Alexander von Humboldt adds a historical twist, linking environmentalism with scientific advancement.