Dr. Hao Wu, the Asa and Patricia Springer Professor of Structural Biology at Harvard Medical School, delves into the exciting world of innate immunity. She explains how cryo-electron microscopy has revolutionized the study of structures like the NLRP3 inflammasome and Gasdermin D. The conversation also highlights the role of AlphaFold in structural biology, revealing how lipid metabolism influences T cell function. Additionally, they discuss innovative approaches to treating peanut allergies, showcasing cutting-edge research in immunology.