Professor Günther Deuschl, a movement disorders expert, and Dr. Robin Wolke, a researcher on levodopa, delve into groundbreaking insights from their award-winning article. They discuss the pivotal role of levodopa responsiveness in predicting outcomes of subthalamic deep brain stimulation. The conversation highlights challenges in patient selection and advocates for personalized medicine to enhance treatment effectiveness, particularly for freezing symptoms. Their research emphasizes the heterogeneous nature of Parkinson's disease and the need for tailored treatment strategies.