Per Olav Vandvik, an expert in the GRADE approach, joins renowned researcher Gordon H. Guyatt for a compelling discussion. They dive into the importance of the GRADE framework for evaluating clinical recommendations. Hear about transforming evidence into practical guidelines while weighing benefits against harms. They also emphasize the role of systematic reviews and the process of assessing evidence certainty, shedding light on how observational studies and randomized trials can inform better patient care.