George W. Bush, the 43rd President of the United States and founder of the George W. Bush Institute, reflects on leadership during crises. He discusses the 20th anniversary of PEPFAR and its impact in combating the AIDS epidemic in Africa. Bush emphasizes the importance of building relationships across party lines and shares insights on crisis management and strategic delegation. He also highlights the necessity of optimism and collaboration in addressing today's challenges, particularly for the younger generation in a post-COVID society.

Jimmy Kimmel talks to Former President George W. Bush about his parents, Donald Trump's inauguration, presidential impersonations, dating Nixon's daughter, and UFO's. They also sketch each other and discuss their journey as artists and their book's donations to veterans.