In this engaging discussion, Dr. Arnold Monto, a veteran in public health and respiratory illnesses, and Dr. Gary McLean, an immunologist specializing in rhinovirus immunity, delve into the mystery of why the common cold remains uncured. They explore the economic burden of colds and the historical efforts to understand them, including the challenges posed by viral diversity. Dr. McLean shares insights on new T cell-focused vaccine approaches aimed at improving immunity, while they both discuss the complexities of traditional vaccine failures and potential future breakthroughs.