Gareth Fraser, an Assistant Professor in Biology, studies tooth evolution, while Zerina Johanson researches vertebrate fossils, and Philip Donoghue specializes in palaeobiology. They explore the origins of teeth, revealing that ancestral vertebrates had none. Sharks can replace thousands, unlike humans. The conversation delves into tooth regeneration and genetic mechanisms, offering insights into potential advancements in dental health. The link between taste buds and teeth is fascinating, alongside the evolutionary transition from scales to true teeth.