Frances Glessner Lee, mother of modern forensic medicine, revolutionized the field with her realistic miniature crime scene dioramas. She made significant contributions to legal medicine, establishing the medical examiner system in Chicago and persuading Harvard to create a Department of Legal Medicine. Frances's impact on criminal justice reform and her meticulous research for a book on anatomy and ancient civilizations are also discussed. The chapter highlights her resilience despite personal tragedies and her efforts to elevate the profession of medical examiner.