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Federico Paoletti, PhD
Co-founder and CEO of Exogene, an Oxford-based biotech combining generative AI and high-throughput lab methods to discover T-cell receptor–based therapeutics and develop a platform for personalized immunotherapy cocktails.
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Oct 1, 2025
• 43min
Putting the “Tech” in Biotech: An Unconventional Path to Building a Therapeutics Company, with Federico Paoletti, PhD
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Federico Paoletti, PhD, co-founder and CEO of Exogene, offers insights into his unconventional journey from academia to biotech entrepreneurship. He discusses the importance of a market-first approach, leveraging AI in personalized immunotherapy, and effective non-dilutive funding strategies. Federico shares lessons from a challenging fundraising trip, emphasizing the need for a broader platform vision. He explores the significance of mentorship and creative hiring to build a lean team, while dispelling myths about AI's role in drug discovery.
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