Dr. F. Douglas Srygley, a gastrointestinal expert, and Dr. David L. Simel, a physician specializing in diagnostics, shed light on the complexities of upper gastrointestinal bleeding. They discuss critical clinical predictors for urgent interventions, emphasizing the significance of patient-reported symptoms. The conversation highlights the limitations of traditional diagnostic tools and the importance of evidence-based practices in enhancing patient outcomes. They also delve into the nuances of diagnostic test performance, offering insights on sensitivity, specificity, and likelihood ratios.