Eric Ravussin, a leading expert on obesity and metabolism, discusses his groundbreaking research on energy expenditure and its influence on aging. He delves into caloric restriction and its health benefits, including insights from the CALERIE study. The episode explores the complexities of measuring energy balance and appetite regulation, highlighting the impact of hormones and dietary habits. Ravussin also examines the potential of GLP-1 agonists and the future of metabolic research through technology and AI advancements.