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Emanuele Zucca
Oncologist and lymphoma researcher at the Oncology Institute of Southern Switzerland; led analyses of the IELSG37 trial on primary mediastinal B-cell lymphoma and discussed implications for frontline regimens and radiotherapy.
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Dec 4, 2025
• 16min
Analysis of IELSG37 Trial Results and PF4 in Stem Cell Aging
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In this discussion, Emanuele Zucca, an oncologist and lymphoma expert, delves into the IELSG37 trial, revealing that the standard R-CHOP21 regimen for primary mediastinal B-cell lymphoma may be less effective than hoped. Sen Zhang, a researcher in pharmacology, explores platelet factor 4's critical role in stem cell aging, highlighting how PF4 deficiency accelerates aging traits in stem cells. Both experts emphasize translational implications for improving therapies and rejuvenating aged hematopoietic stem cells, sparking new hope in regenerative medicine.
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