In this insightful discussion, James Tibenderana, Chief Executive at the Malaria Consortium, shares vital advancements in malaria control for 2025, including breakthroughs in vaccine rollout and new treatment strategies. Abdoulaye Djimdé, Professor of Parasitology, details the clinical success of a new drug, Ganaplacide-lumefantrine, and its unique mechanism against resistance. Ellie Sherrard-Smith explains the innovative passive spatial emanators designed for indoor mosquito control, highlighting their role in reducing malaria transmission. The stakes are high amid funding cuts affecting global health initiatives.