Dr. Yao, a researcher in preventive cardiology, and Dr. Blaha, from Johns Hopkins, explore the complexities of obesity classification. They discuss the discrepancies between clinical and anthropometric definitions, emphasizing waist measurements over traditional BMI. The conversation highlights the prevalence of preclinical obesity in normal-weight individuals, the challenge of metabolically healthy obesity, and the need for nuanced definitions in obesity-related research. Real-world data from programs like All of Us are portrayed as vital for future studies.