Join Dr. Karen Reckamp, a medical oncologist focused on neoadjuvant strategies, Dr. Scott Oh, a radiation oncologist discussing local therapies, and Dr. Scott Atay, an interventional pulmonologist specializing in staging, as they tackle a complex NSCLC case. They debate the best approaches for treating isolated brain metastasis, the implications of nodal disease, and the optimal sequencing of chemoimmunotherapy and radiation. Their multidisciplinary insights shed light on the balance between surgical risks and systemic benefits in challenging cancer cases.