Dr. Sanjeev Saksena

Electrophysiologist and academic medical leader with expertise in atrial fibrillation mechanisms and therapies; serves as professor of medicine and medical director of an electrophysiology research foundation and contributed expert commentary on TRANSFORM-AF.

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Oct 29, 2025 • 22min

432. Journal Club: The TRANSFORM-AF Trial with Dr. Sanjeev Saksena and Dr. Varun Sundaram

In this discussion, Dr. Varun Sundaram, a renowned cardiologist focused on heart failure, and Dr. Sanjeev Saksena, an expert electrophysiologist, delve into the TRANSFORM-AF Trial's groundbreaking findings. They explore how GLP-1 receptor agonists may reduce atrial fibrillation events in diabetic patients with obesity. The trial revealed a significant 13% decrease in AF-related hospitalizations and emphasized the need for early intervention in managing AF. Additionally, they discuss the potential of GLP-1 benefits beyond weight loss and the crucial role of inflammation in AF and heart failure.

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