Dr. Rebecca Carpley, a hematologist at Massachusetts General Hospital, dives into the complexities of hypercoagulability and the nuances of clot management. She discusses reframing clots by reversibility, shedding light on how Virchow's triad categorizes clot etiology. Dr. Carpley addresses inherited protein deficiencies, emphasizing factors influencing testing. The conversation also examines the reliability of genetic tests like Factor V Leiden, considering the critical role of family history in assessing thrombosis risks. Insights into individualized care for women of childbearing age add depth to this engaging discussion.