Dr. Michael Insa, a primary care and addiction medicine physician at the University of Utah, teams up with Dr. Heather Stieglitz, a clinical analytical toxicologist at The Ohio State University. They dive into the intricacies of urine drug screening, including common false positives and negatives. The conversation emphasizes the importance of confirmatory tests and patient-centered approaches. They also discuss the sensitive nature of screenings, advocating for empathetic communication and motivating patients to engage in open discussions about substance use.