Dr. Mark Dybul, former U.S. Global AIDS Coordinator and leader of PEPFAR, shares insights from his pivotal role in saving 20 million lives through innovative health initiatives. He discusses groundbreaking strategies to prevent mother-to-child HIV transmission in Africa and the challenges of funding and implementing effective treatment. Dybul also highlights the necessity of bipartisan support and collaboration between governments and NGOs in advancing health policies while reflecting on the ethical complexities faced in public health.