Dr. Lisa R. Sammaritano, a leading expert in lupus at Weill Cornell Medicine, discusses the groundbreaking updates to the ACR Lupus Nephritis Guideline, a decade in the making. She shares insights on innovative treatment strategies, including combination therapies and the push to minimize glucocorticoid use for better patient outcomes. The conversation highlights the unique needs of both pediatric and adult patients, the promise of a triple therapy approach, and challenges in managing class 5 lupus nephritis, emphasizing the importance of individualized care.