Dr. Kinna Thakarar, an infectious disease specialist, Dr. Ayesha Appa, a patient-centered care advocate, and Chastity Tuell, a harm reductionist, spotlight critical topics in addiction and infection management. They discuss innovative harm reduction strategies and the importance of shared decision-making for drug users. The conversation also sheds light on rural healthcare barriers and the stigma surrounding substance use. Personal anecdotes highlight cultural joys, all while emphasizing a patient-centered approach to improve health outcomes in vulnerable communities.