Dr. John Seal, a transplant and hepatobiliary surgeon at Ochsner Clinic, joins transplant hepatologists Dr. Heather Patton and Dr. Stephen Young to discuss the complexities of liver transplantation. They explore the multidimensional pre-transplant evaluation process, the significance of the MELD score, and manage challenges like portal vein thrombosis. Innovations in treating hepatocellular carcinoma (HCC) are highlighted, emphasizing emotional support for patients. The conversation also touches on groundbreaking advancements in transplantation practices, reshaping future possibilities.