Dr. Austin Smith, a leading researcher in stem cell biology at the University of Cambridge, discusses the intricacies of pluripotency. He shares his insights on the essential components of the pluripotency network and the challenges of modeling these systems. The conversation explores the significance of the gene Nanog in embryonic stem cells, along with implications for regenerative medicine. Smith also delves into the fascinating roles of inhibitors like GSK3 in stem cell differentiation and the evolving landscape of scientific integrity.