Dr. Amy Drendel, a pediatric emergency medicine physician and researcher at Children’s Wisconsin, discusses an intriguing case of a 14-year-old boy with sickle cell disease facing a painful vaso-occlusive episode. She highlights the promising role of intranasal fentanyl in improving pain management and expediting discharge from emergency departments. The conversation dives into the challenges of opioid administration, the potential efficiencies of intranasal versus intravenous methods, and the need for further research to enhance care for pediatric patients.